Natural ingredient with scientifically validated and clinically proven cognitive benefits

Sibelius®: Sage is a high-quality natural ingredient with proven cognitive benefits, marketed through leading regional distributors to nutraceutical manufacturers and MLMs.

WHY SAGE

Sage (Salvia officinalis L.) is a well-known medicinal herb native to Europe that has a long tradition for cognitive enhancement dating back to ancient times (Lopresti, 2017). Clinical studies have demonstrated sage’s cognitive benefits on primary, secondary and working memory in both healthy young and elderly volunteers (Kennedy et al, 2006 & Scholey et al, 2008). Sage extracts have been shown to inhibit acetylcholinesterase, an enzyme that breaks down esters of the neurotransmitter acetylcholine, which plays an important role in the formation of memories (Hasselmo, 2006). They also possess strong antioxidant, anti-inflammatory and estrogenic properties. 

WHAT IS SIBELIUS®: SAGE?

It is a branded, scientifically evidenced and clinically validated dried sage extract (Salvia officinalis L.) , specially designed to enhance secondary memory and alertness and maintain cognitive health. It derived from a proprietary, non-GMO cultivar of sage grown in the UK and is standardised to 2.5% rosmarinic acid.

One of the activities of Sibelius®: Sage that is likely to contribute to the improved cognitive performance is the inhibition of acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine. This anti-AChE activity is shared by several drugs used in the treatment of early symptoms of Alzheimer’s Disease, and likely contributes towards Sibelius: Sage’s anti-ageing effects.

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CLINICAL STUDIES

  • Improved Memory and Attention in Older Volunteers

The cognitive-enhancing properties of Sibelius®: Sage have been confirmed in Sibelius Natural Products’ clinical study conducted with a cohort of healthy seniors (Scholey et al, 2008). Testing of the cohort showed significant improvements in memory performance of recognition and recall, as well as accuracy of attention over periods of between one and six hours (1-6 h), in response to a single dose of 333 mg.

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  • S. officinalis better Cognitive Performance than S. lavandulifolia

In 2010, a clinical study of Salvia officinalis and Salvia lavandulifolia essential oils investigated the effect on cognition and mood in 135 healthy adults. The S. officinalis group performed significantly better than the S. lavandulifolia and control groups on the quality of memory and secondary memory (Moss et al, 2010).

  • Improved Cognitive Performance in Young Adults

In a double blind, placebo controlled cross over study, 30 healthy participants (20-29 years old) were given a Salvia officinalis extract or placebo and tested for stress, mathematical processing, response time, memory and mood. Improved mood and cognitive performance were noted after a single dose administration of 300 mg sage extract (Kennedy et al, 2006).

OTHER STUDIES

The challenge has been to identify the unique characteristics of Sibelius®:Sage over other sage extracts, obtained from different sources and extraction procedures. Using ChronoscreenTM , Sibelius’ patented technology, we have been able to demonstrate that there is a significant difference in the biological activity of Sibelius®:Sage extract, over that of other extracts. 

Chronological Life Extension (CLS Extension) is measured using Sibelius’ patented ChronoscreenTM technology, and allows for the identification of biologically active natural products in the model organism C. elegans. Sibelius®: Sage shows increases in lifespan of around 10-15%.