Derek Lowe, Corante

Blog post validating the Sibelius/Chronos method of screening for an activity or phenotype over target based screening. The post discusses a Review from Nature Drug Discovery which focuses on the different types of preclinical strategies that are used to identify potential drug candidates. These strategies include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches.

They have investigated which of these strategies have been more successful than others in the discovery of new drugs. By analysing new molecular entities and new biologics that were approved by the US Food and Drug Administration between 1999 and 2008 they have found the contribution of phenotypic screening to the discovery of first-in-class small-molecule drugs exceeded that of target-based approaches.

Full article:  Phenotypic Screening For the Win