Looking for science to determine your development direction?

Chronoscreen™ is a testing solution for whole extracts that allow for confident analysis to aid the selection of the best ingredients from the best source to further enhance development in consumer health products.

The patented screening tool allows for the discovery, evaluation, and monitoring of biologically active natural products. The technology is used to identify the best sources for existing ingredients and drills down past the usual measures; looking at the actual activity offered from a particular botanical source.

✔ Gain invaluable insights on complex extracts to drive further decision making and manage risk before committing to clinical trials

✔ Gain a competitive advantage for finished products and formulations with access to a new level of understanding of extracts

✔ Expand product pipelines with new evidence to support product innovation and suggest potential synergistic combinations

✔ Give products a route to patent protection by highlighting distinction biologically active ingredients

Chronoscreen™  has also won an Innovate UK Smart Award to develop a novel method to identify the individual compounds within complex natural products that interact with human proteins to impart beneficial effects on health

THE CHRONOSCREEN™ PLATFORM

Chronoscreen™ utilizes the roundworm, Caenorhabditis elegans (C. elegans), a whole organism model with many physiological similarities to humans including a digestive and nervous system.

Chronoscreen™ measures the lifespan in populations of C. elegans and their responses to different nutraceutical ingredients.

 

Extension of lifespan on Chronoscreen™ indicates that the tested ingredient had a beneficial effect on the regulation of cellular ageing and therefore may have a delayed onset of age-related conditions in the worm.

Given the strong correlation of the pathways of cellular ageing between species, our premise is that these ingredients should also have beneficial effects on human health.

The Chronoscreen™ platform can be successfully applied for biological testing of a broad range of natural ingredients. It can identify and confirm the evidence of their potential health benefits, from which we can then determine the pathways essential for the ingredient’s activity. This helps to address consumer demands and concerns as well as regulatory and policy issues.

THE SCREENING PROCESS

Chronoscreen™ allows the identification of interesting botanicals and selection of specific high quality, robust and sustainable sources. The Chronoscreen™ platform takes whole extracts on a three-step process:

1) Identifying botanicals

This first step of the process is to identify what indications and markets to target. Using this information, the platform screens across a range of different botanical extracts to identify those that are worthy of further investigation. 

2) Selecting sources:

Once the different botanicals have been tested, the next step is to compare the different sources of the selected ingredient. This step identifies the source that shows the greatest increase in medium lifespan.

3) Validating selected sources

To validate the source, the Chronoscreen process identifies the potential suppliers for the selected source against:

– Quality

– Robustness

– Sustainability

The biological activity is then compared across multiples batches to ensure consistency.

WHAT’S NEXT?

Once the three-step process of the Chronoscreen™  platform is completed, we can guide our customers through molecular phenotyping, Mechanism Of Action (MOA) validation through to clinical validation.

THE PROOF IS IN THE SAGE

Chronoscreen™ has gained high interest in the nutraceutical, cosmeceutical and functional food & beverage industries. Sibelius has already tested more than 750 natural ingredients.

One way Sibelius has gained traction of Chronoscreen™  is through the award-winning ingredient Sibelius™: Sage.

 

Contact us today to receive the case study and learn how Chronoscreen™ can drive your ingredient research and development forward.