Sibelius Natural Products partners with Oxfordshire Mind

Sibelius Natural Products has released its Corporate Social Responsibility (CSR) policy and announced a two-year partnership with Oxfordshire Mind, a mental health charity providing support to individuals experiencing mental health issues.

Read the full article on the Nutraceutical Business Review website here.

 


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Sibelius reaffirms CSR commitment with policy, announces partnership with Oxfordshire Mind

Oxford, UK, 29 January 2020 – Sibelius Natural Products, developers of high-quality, scientifically evidenced and clinically proven natural ingredients for the nutraceutical market, today reaffirmed its commitment to sustainability and ethical business practice with the release of its Corporate Social Responsibility (CSR) policy. Sibelius also announced a two-year partnership with Oxfordshire Mind, a mental health charity providing support to individuals experiencing mental health issues.

Sibelius’ CSR policy is founded on the UN’s Sustainable Development Goals, ensuring that the company’s business operations fall in line with the top issues and priorities facing the planet. The policy focuses on three goals:

  • Ensuring healthy lives and well-being for all (SDG 3)
  • Ensuring quality education and life-long learning for all (SDG 4)
  • Sustainable consumption and production patterns (SDG 12)

“Our CSR policy puts sustainability at the heart of our business model,” said Peter Leyland, CEO of Sibelius Natural Products. “We see this as an essential aspect of informing and framing all our activities and capabilities as our company continues to expand.”

Sibelius’ CSR policy also establishes a commitment to charitable giving; particularly to charities and initiatives in the community which fit alongside the company’s mission and pledge to the SDGs. Sibelius has therefore signed a two-year partnership with Oxfordshire Mind – a local mental health charity whose mission is to promote good mental health through a variety of high quality services and campaigning.

Commenting on the partnership, Dan Knowles, CEO of Oxfordshire Mind said: “We are delighted that Sibelius has chosen to partner with Oxfordshire Mind for the next two years.  Funds raised will help us to provide invaluable advice and support to people across our community.”

The partnership is influenced by Sibelius’ commitment to providing a healthy, supportive work environment for all team members. During the two-year period, the company aims to raise over £2,000 through a variety of team activities, including the Blenheim 7k race, bake sales, raffles, quizzes and more.

“Emotional and mental wellbeing are vital parts of life and should be taken just as seriously as physical wellbeing,” said Leyland. “We are very excited to be partnering with Oxfordshire Mind, and our team looks forward to supporting individuals around Oxfordshire with mental health issues through our fundraising efforts.”

To learn more about Sibelius’ Corporate Social Responsibility policy and Oxfordshire Mind, click here.


Sibelius™: LactoMato is the new natural ingredient for Men’s Health – White Paper by David Foreman

Download our whitepaper below to learn about Sibelius™:LactoMato – a new natural solution to support male reproductive and prostate health.

The average male seems to not care about health until it is too late.  It’s no shock that men seem to have more serious health issues than women.1 Venturing a guess as to why? Maybe it is because men never seem to go to the doctor unless there is something serious. Women, on the other hand, go to the doctor yearly for their exams, and therefore other health issues such as high blood pressure, diabetes, weight issues can be caught in the earlier (easier to treat) stages. Don’t you think it is time for men to take charge of their lives and be pro-active about their health?

When speaking of “Men’s Health” two primary areas rise to the top; genitourinary (reproductive organs and urinary system) and cardiovascular health.  The genitourinary system, in particular, receives a lot of press with the abundance of commercial advertisements around prostate health and erectile dysfunction.  Cardiovascular diseases, on the other hand, are the number 1 cause of death globally, taking an estimated 17.9 million lives each year.  Cardiovascular health also receives an abundance of attention in the media with commercials regarding cholesterol, atrial fibrillation, and blood thinners.  Considering these two broad areas are of significant impact in men’s health, it seems appropriate to discuss a new form of an existing ingredient that provides benefits in both of these areas:

New From = Sibelius™: LactoMato, Existing Ingredient = Lycopene.

DOWNLOAD THE WHITEPAPER:

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1 WHO. Global Health Observatory (GHO): Female Life Expectancy. [Online] [Accessed January 16, 2020]
[https://www.who.int/gho/women_and_health/mortality/situation_trends_life_expectancy/en/]

About David Foreman
David Foreman is a pharmacist, author and media personality known internationally as, “The Herbal Pharmacist®.” His background in both pharmacy and natural medicine puts David in an elite class of health experts who can teach integrative medicine practices. David’s focus is to help all to achieve the health and vitality they seek by teaching his 4-Pillars of Health: Diet, Exercise, Spirituality and Supplements. David is also highly sought for his abilities as a science engineer by helping companies connect their science to their sales and marketing teams. David is a graduate of the University of South Carolina College of Pharmacy, currently serves on Organic & Natural Health Association’s Scientific Advisory Board and is author of, “4 Pillars of Health: Heart Disease.”


Healthy aging: Living better, not just longer – podcast

Kieron Edwards, Ph.D., of Sibelius Natural Products, discusses the physical implications of aging, along with strategies to help support living well for the long haul.

Listen to the full podcast on the Natural Products Insider website here.


Our year in review

Summer away day, June 2019

2019 has been a year of building momentum on all fronts by the Sibelius Natural Products team. We completed our evaluation project on hemp products; taking our investigations as far as we could within the UK regulatory environment. Given the ability of Chronoscreen™ to discriminate between a wide variety of parameters, we entered into a joint venture, Seneb Products, to continue this work for Marijuana-based products in Canada, where there is a more open regulatory environment.

On completing the hemp project, we have focused our UK laboratory’s work exclusively on in-house development for a period of 12 months. This is allowing us to create a portfolio of product opportunities that meet the maximum number of indications allowable under nutraceutical regulations.

As we close the year, we now have three ingredients on the market – Sibelius™:Sage, Sibelius™:Chamomile and Sibelius™:LactoMato. They already cover a broad range of indications: Cognition, Focus, Energy, Sleep, Calming, Immune, Cardiovascular, Men’s Health and Skin Care. In each of the next four years, our plan is to launch two new ingredients having used Sibelius’ in-house development platform Chronoscreen™ to guide us.

Along with the development of our products and indications, in 2019 we have focused on the global expansion of our distribution network; particularly  into East Asia. We have seen tremendous ingenuity by our downstream clients to formulate and manufacture a wide variety of delivery formats for our products, including tablets, capsules, powders, gummies, jellies, drinks and gums. They have also just begun investigating cosmeceutical and animal health products.

2020 will throw up new challenges as we reopen the Chronoscreen™ laboratory for client work once again. We’ll also be expanding into the UAE/GCC countries and Europe, and continue the rapid pace of our new product introductions.

Wishing you a happy holiday and a healthy 2020,

Peter Leyland
CEO


All you need to know about Natural Lycopene

Introducing Lycopene

Lycopene molecule_ Sibelius LactoMato

Lycopene is a lipophilic carotenoid compound, found predominantly in tomatoes and other red fruits and vegetables, including watermelon, papaya and guava. Lately, lycopene has been extensively studied in numerous epidemiological, experimental and clinical trials for its potential beneficial effects on human health, displaying antioxidant, anti-inflammatory, anti-proliferative and cardioprotective activities1. It’s also considered to be one of the most powerful antioxidants, being 10 times stronger than alpha-tocopherol and twice as potent as beta-carotene2. Since it is a lipophilic molecule, it helps prevent lipid peroxidation, as well as protects against DNA damage by inducing enzymes of the cellular antioxidant defence system3.

Lycopene bioavailability from fresh tomatoes is very low in humans, while thermal treatment and processing improve its absorption. Processed tomato-based products, such as tomato juice, paste, ketchup and soup, provide lycopene with enhanced bioavailability3. However, in order to benefit from the effects, these would need to be consumed in large amounts each day4. Natural lycopene supplement formulations present an easier and effective way to improve lycopene absorption and avoid the consumption of highly processed foods, which often contain a long list of unknown ingredients5.

Beneficial Effects

Lycopene has been shown to support different areas of human health:

  • Cardiovascular Health
    Lycopene has been widely studied for its cardiovascular activities, indicating improvements to endothelial and metabolic function, as well as blood pressure control 3, 6-8
  • Prostate Health
    Increased lycopene intake has been widely investigated in several epidemiological and clinical trials, showing to support prostate health by reducing oxidative DNA damage and inducing specific enzymes that protect against exogenous toxins9, 10
  • Male Fertility Health
    Lycopene supplementation has been reported to decrease lipid peroxidation and DNA damage, and subsequently improves sperm quality, including sperm count, viability and normal morphology11, 12

What is Sibelius™:LactoMato?

Sibelius™:LactoMato is a unique proprietary, patented formulation, in which natural tomato extract, standardised to lycopene, has been embedded in a whey protein matrix. This minimises particle size, resulting in enhanced absorption. The bioavailability of Sibelius™:LactoMato has also been tested in a healthy volunteer trial, and lycopene in our formulation was found to be 240% more bioavailable than raw lycopene from fresh tomatoes5.

Sibelius™: LactoMato was developed following years of research into the Mediterranean diet and lycopene’s health-promoting properties. It has been subject to several clinical studies in the areas of cardiovascular and men’s health. Sibelius™:LactoMato’s latest study has focused on the area of male reproductive health, with fifty-six healthy men receiving the product for 12 weeks. This daily supplementation significantly improved sperm quality by around 40%, as measured by the proportion of fast progressive sperm and sperm with normal morphology12.

Sibelius will continue to expand the understanding of how Sibelius™: LactoMato works and can benefit each health category. Contact us to learn more.

By Loukiana Chatzinasiou
Product Manager

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1 Kerkel, M. et al. Review Article: Antioxidant and anti-proliferative properties of lycopene. Free Radical Research, 2011; 45(8): 925-940.
2 Agarwal, S. and Rao, A. K. Tomato lycopene and its role in human health and chronic diseases. CMAJ, 2000; 163(6): 739-744.
3 Mozos, I. et al. Review: Lycopene and Vascular Health. Frontiers in Pharmacology, 2018; 9(521): 1-16.
4 Story, E.N. et al. An Update on the Health Effects of Tomato Lycopene. Annu Rev Food Sci Technol, 2010; 1: 1-24.
5 Richelle, M. et al. A Food-Based Formulation Provides Lycopene with the Same Bioavailability to Humans as That from Tomato Paste. Human Nutrition and Metabolism, 2002; 404-408.
6 Gajendragadkar, P. R. et al. Effects of Oral Lycopene Supplementation on Vascular Function in Patients with Cardiovascular Disease and Healthy Volunteers: A Randomised Controlled Trial. PLOS ONE, 2014; 9(6).
7 Cheng, H.M. et al. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis; 2017; 257: 100-108.
8 Perveen, R. et al. Tomato (Solanum lycopersicum) Carotenoids and Lycopenes Chemistry; Metabolism, Absorption, Nutrition, and Allied Health Claims- A Comprehensive Review. Critical Reviews in Food Science and Nutrition, 2013; 919-929.
9 Chen, P. et al. Lycopene and Risk of Prostate Cancer. Medicine (Baltimore), 2015; 94(33): e1260.
10 Wertz, K. Lycopene Effects Contributing to Prostate Health. Nutrition and Cancer, 2009; 61(6): 775-783.
11 Majzoub, A. and Agarawal, A. Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab J Urol, 2018; 16(1):113-124.
12 Williams, E.A. et al. A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. European Journal of Nutrition, 2019; 1-9.


Sibelius Lycopene Formulation Supports Reproductive, Prostate & Cardiovascular Health

Sibelius Natural Products has launched its proprietary lycopene (LactoLycopene) extract, Sibelius: LactoMato, a unique formulation made from tomato oleoresin that’s backed by multiple clinical studies demonstrating its ability to support male reproductive health, prostate health, and cardiovascular health. The novel ingredient will be distributed by its North American partner, Barrington Nutritionals.

Read the full article on the Nutraceuticals World website here.


The History of C. elegans

The history of Caenorhabditis elegans (C.elegans) in research begins with one of the leading biologists of the 20th century – Sydney Brenner. In the 1960s, Brenner developed an insight into using C. elegans as a genetic model for understanding questions of developmental biology and neurobiology. Nearly 40 years later, in 2002, he was awarded the Nobel Prize in Physiology or Medicine for the establishment of C. elegans as a novel model organism for human-disease research.

What is C. elegans?

C.elegans is a microscopic, 1mm long free-living nematode found in soil around the world. The miniscule size of C. elegans suggests the use of microscopes in order to observe behavioural aspects of its life, or to conduct more detailed investigations down to the cellular level1.

C.elegans worms mainly reproduce via ‘female’ hermaphrodite self-fertilisation and can produce up to 300 self-progeny. Females can also reproduce with “male” worms, however the latter occurs at a frequency of less than 0.2%. During their short life cycle of approximately 3 days, eggs pass through 4 larval stages upon hatching (L1-L2-L3 and L4) through to adulthood, and gravid worms can also lay their own eggs.

Worms are usually maintained and grown at temperatures between 12-25°C. Unlike humans, they are unable to regulate their temperature and are consequently temperature sensitive. This suggests that a worm maintained at a temperature of 15°C, for example, will grow at a slower rate compared to one maintained at 20°C1.

C. elegans in research

The assessment of the main characteristics of C. elegans already shows its potential to be a good candidate for biological research. However, there are several other notable features which support C. elegans as a well-established model organism and a cornerstone of research.

Firstly, the C. elegans organism is easy and quick to grow and affordable to maintain. As mentioned previously, they produce a significant number of progeny – starting from a single worm within a few days, leading to an extensive population at various stages of development and adult life1.

In addition, the transparent body of C. elegans provides a great avenue for internal organs and cells to be extensively studied and observed. The invariant number of its somatic cells enable researchers to track the fate of every cell between fertilization and adulthood in live animals, and generate a complete cell lineage2,3.

C. elegans was also the first multicellular organism to have its genome completely sequenced4. As a result, further research identified extraordinary links to the biological and genetic relationship between C. elegans and the advanced human organism. Indeed, 60-80% of human genes have an orthologs (functional counterpart) in the C. elegans genome5 and 40% of genes known to be associated with human diseases have clear orthologs in the C. elegans genome6.

The latter, accompanied with the ease of introducing mutations into C. elegans, makes it a great candidate for creating human disease models, including ageing.

Sibelius’ patented Chronoscreen™ profiling platform utilises C. elegans to rapidly identify natural ingredients and products with the potential to support all stages of healthy aging through healthspan improvement. With this, we support the nutraceutical and cosmeceutical industries with access to natural product screening, biological activity identification and rapid product development. Contact us to learn more.

By Sotirios Kleidonas
Laboratory Operations Manager

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1 Wormbook: The Online Review of C. elegans Biology [Online] [Accessed: September 2019][Available:  http://www.wormbook.org/]
2 Sulston, JE and HR Horvitz. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. (1977); 56: 110-156.
3 Kimble, J. and D. Hirsh. The post-embryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev. Biol. (1979); 70: 396-417.
4 The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science (1998): 2012-2018.
5 Kaletta, T and Hengartner, MO. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. (2006); 5: 387-398.
6 Culetto, E and Sattelle, DB. A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum. Mol. Genet. (2000); 9: 869-877.


Sibelius Debuts Chamomile Extract for Sleep Support & Immune Health

Sibelius Natural Products has launched its latest botanical ingredient, Sibelius: Chamomile. Extracted from Roman chamomile, which is known for its strong antioxidant and relaxing properties, the new ingredient will be distributed by Sibelius’ North American partner, Barrington Nutritionals.

Read the full article on the Nutraceuticals World website here.